Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Lys-bradykinin TFA | 99.9% | 1188.38 g/mol | C56H85N17O12 · x C2HF3O2 | 50 MG
Lys-Bradykinin TFA is the trifluoroacetate salt of Lys-Bradykinin (kallidin), a biologically active nonapeptide ligand for bradykinin/kallidin receptors. Supplied as a solid peptide powder for research use, it is commonly used in studies of vascular regulation, inflammation, and receptor pharmacology.
- Trifluoroacetate salt of Lys-Bradykinin (kallidin).
- Purity 99.85%.
- Molecular weight 1188.38 g/mol.
- Available as solid powder, including 50 MG size.
- Storage: powder -80°C for 2 years, -20°C for 1 year; in solvent -80°C for 6 months, -20°C for 1 month.
- Documentation includes COA, RP-HPLC, LCMS, elemental analysis, and SDS.
Medchemexpress LLC Amg 7905 (tfa) | 00-00-0 | 99.1% | 597.58 | C27H25F6N5O2S | 5 MG
AMG 7905 TFA is the trifluoroacetate salt of AMG 7905, a potent transient receptor potential vanilloid 1 (TRPV1) antagonist used in research. It potentiates proton-enhanced TRPV1 activation while blocking capsaicin-induced channel responses, and has been used to study thermoregulation and TRP channel physiology. The compound is supplied as a high-purity research reagent for in vitro and in vivo studies.
- Potent TRPV1 antagonist activity.
- Modulates proton-enhanced channel activation and blocks capsaicin responses.
- High purity (≈99.1%).
- Provided as the trifluoroacetate (TFA) salt to aid handling and solubility.
- Available in small research pack sizes suitable for pilot studies.
- Intended for laboratory research use only.
Medchemexpress LLC Vu0364572 TFA | 1240514-89-9 | MFCD31618417 | 99.3% | 487.51 g/mol | C23H32F3N3O5 | 5 MG
VU0364572 TFA is the trifluoroacetate salt of a selective M1 muscarinic receptor agonist intended for use in in vitro and in vivo pharmacology research. It is supplied as a high-purity solid powder for laboratory research applications.
- High purity (99.3%) suitable for research use.
- Trifluoroacetate salt form to aid solubility and handling.
- Solid powder form for convenient weighing and formulation.
- Available in small pack sizes appropriate for discovery and preclinical studies.
- Recommended sealed storage away from moisture and light; follow solvent storage guidelines for long-term stability.
TARGETMOL CHEMICALS INC MM-102 TFA 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor with an IC50 of 2.4 nM. This compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5), inhibiting MLL1 H3K4 histone methyltransferase (HMT) activity and down-regulating H3K4me3, which facilitates the epigenetic reprogramming of porcine somatic cell nuclear transfer embryos. Purity 99.3%
Medchemexpress LLC MM-102 trifluoroacetate | 1883545-52-5 | 99.7% | 2 MG
MM-102 TFA is the trifluoroacetate salt of MM-102, a research reagent that inhibits the WDR5/MLL protein-protein interaction. It is supplied as high-purity solid and as DMSO solution formats for biochemical and cellular studies, with reported potency in WDR5 binding assays.
- Potent inhibitor of the WDR5/MLL protein-protein interaction.
- Reported IC50 = 2.4 nM in WDR5 binding assay.
- High reported purity (99.68%).
- Available in small solid quantities and as 10 mM in DMSO solution.
- Trifluoroacetate salt form for convenient handling and solubility.
Medchemexpress LLC Lys-bradykinin trifluoroacetate | 99.9% | 1188.4 g/mol | C56H85N17O12 · x C2HF3O2 | 5 MG
Lys-bradykinin trifluoroacetate is the trifluoroacetic acid (TFA) salt form of the peptide Lys-Bradykinin (kallidin 380-389). It is supplied as a purified powder for research applications where it serves as a ligand for kallidin and bradykinin receptors. Reported purity is 99.85% and the free-base molecular weight is 1188.38 g/mol.
- TFA salt of Lys-Bradykinin peptide.
- High purity (99.85%).
- Provided as a solid powder suitable for dissolution in common solvents.
- Recommended storage: sealed, protected from moisture and light; powder stable at -80°C for up to 2 years.
- Intended for research use as a ligand in receptor binding or signaling studies.